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Scientific Research & Evidence


"Role of calcium in brain aging"
General Pharmacology: The Vascular System, Volume 26, Issue 8
Pietro Gareri, Rosario Mattace, Felice Nava, Giovambattista De Sarro2

"The role for vitamin B-6 as treatment for depression: a systematic review"
Anna-Leila Williams, Anne Cotter, Alyse Sabina, Christine Girard, Jonathan Goodman, David L Katz
Fam Pract . 2005 Oct;22(5):532-7. doi: 10.1093/fampra/cmi040. Epub 2005 Jun 17.

"Magnesium intake and depression in adults"
Emily K Tarleton 1, Benjamin Littenberg 2
Journal of the American Board of Family Medicine: Mar-Apr 2015;28(2):249-56. doi: 10.3122/jabfm.2015.02.140176.

"Melatonin and Microglia"
Rüdiger Hardeland 1
International Journal of Molecular Sciences: 2021 Aug 2;22(15):8296. doi: 10.3390/ijms22158296.

"Central depressant and nootropic effects of daytime melatonin in mice"
Olakunle J Onaolapo,1 Adejoke Y Onaolapo, M.B.B.S.,2,* Akanni A Abiola,2 and Eniafe A Lillian2
Ann Neurosci. 2014 Jul; 21(3): 90–96., doi: 10.5214/ans.0972.7531.210304

"Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders"
Eduardo Ferracioli-Oda, Ahmad Qawasmi, and Michael H. Bloch
PLoS One. 2013; 8(5): e63773. Published online 2013 May 17. doi: 10.1371/journal.pone.0063773

"The Efficacy of Oral Melatonin in Improving Sleep in Cancer Patients with Insomnia: A Randomized Double-Blind Placebo-Controlled Study"
Madhuri S Kurdi and Sindhu Priya Muthukalai
Indian J Palliat Care. 2016 Jul-Sep; 22(3): 295–300. doi: 10.4103/0973-1075.185039

"A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning"
Asako M Kikuchi, Aya Tanabe, Yoshihiro Iwahori
Journal of Dietary Supplements. 2021;18(3):316-333. doi: 10.1080/19390211.2020.1746725. Epub 2020 Apr 10.

"A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice, GoChi"
Harunobu Amagase, Dwight M Nance
Journal of Alternative and Complementary Medicine . 2008 May;14(4):403-12. doi: 10.1089/acm.2008.0004.

"The treatment of Goji berry (Lycium barbarum) improves the neuroplasticity of the prefrontal cortex and hippocampus in aged rats"
Ana Karen Ruíz-Salinas, Rubén A Vázquez-Roque, Alfonso Díaz, Guadalupe Pulido, Samuel Treviño, Benjamín Floran, Gonzalo Flores
Journal of Nutritional Biochemistry. 2020 Sep;83:108416. doi: 10.1016/j.jnutbio.2020.108416. Epub 2020 May 17.

"A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality"
A Ngan, R Conduit
Phytotherapy Research. 2011 Aug;25(8):1153-9. doi: 10.1002/ptr.3400.

"The Sedative Effect of Non-Alcoholic Beer in Healthy Female Nurses"
Lourdes Franco, Cristina Sánchez, Rafael Bravo, Ana B. Rodríguez, Carmen Barriga, Eulalia Romero, and Javier Cubero
PLoS One. 2012; 7(7): e37290. Published online 2012 Jul 18. doi: 10.1371/journal.pone.0037290

"Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review"
Piril Hepsomali, John A. Groeger, Jun Nishihira, and Andrew Scholey
Front Neurosci. 2020; 14: 923. Published online 2020 Sep 17. doi: 10.3389/fnins.2020.00923

"Effects of l-theanine on attention and reaction time response"
Akiko Higashiyamaa, Hla Hla Htayb, Makoto Ozekib, Lekh R. Junejab, Mahendra P. Kapoorb
Journal of Functional Foods, Volume 3, Issue 3, July 2011, Pages 171-178

"Controlled trials of inositol in psychiatry"
J Levine
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 1997 May;7(2):147-55. doi: 10.1016/s0924-977x(97)00409-4.

"l-5-Hydroxytryptophan in depression: the first substitution therapy in psychiatry? The treatment of 99 out-patients with 'therapy-resistant' depressions"
L J van Hiele
Neuropsychobiology . 1980;6(4):230-40. doi: 10.1159/000117757.

"Anti-oxidative and DNA protecting effects of flavonoids-rich Scutellaria lateriflora"
Madhukar Lohani, Manuj Ahuja, Manal A Buabeid, Schwartz Dean, Shannon Dennis, Vishnu Suppiramaniam, Barbara Kemppainen, Muralikrishnan Dhanasekaran
Natural Product Communications. 2013 Oct;8(10):1415-8.

"The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm"
L Franco, C Sánchez, R Bravo, A Rodriguez, C Barriga, Javier Cubero Juánez
Acta Physiologica Hungarica. 2012 Jun;99(2):133-9. doi: 10.1556/APhysiol.99.2012.2.6.